I would assume the way Sega Naomi reads off the SCSI bus is different but then again, it's definitely the SCSI spec so maybe it'd work?
http://wiki.pcbotaku.com/wiki/Naomi_DIY_CF_box (http://wiki.pcbotaku.com/wiki/Naomi_DIY_CF_box)
SCSI-2 expects 10mhz transfers, SCSI-1 only 5mhz. While SCSI-2 interfaces may be able to use SCSI-1 drives, it may not be possible to use a SCSI-2 drive with a SCSI-1 interface.
Really though, with the SD2SCSI available, why bother converting CF to SCSI.
The Naomi stuff isn't really SCSI. (The CF adapters are just talking old ATA/IDE command sets.) They just happen to use the SCSI-2 like cabling. (They also use USB cables for RS-422/485 like signaling-- just taking advantage of cheap/available stuff from the PC market instead of doing custom stuff.)